Regulation of nitric oxide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of nitric oxide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPX3, PRMT5, and TNS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric oxide metabolic process activity versus GPX3 in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPX3 →	+0.614	+0.066	<.001	<.001	3	9
OV	PRMT5 →	-0.446	-0.052	<.001	.001	3	9
BRCA	TNS1 →	+0.485	+0.034	<.001	<.001	3	9
BRCA	TNS2_S120 →	+0.530	+0.043	<.001	<.001	3	9
OV	WIPF1 →	+0.635	+0.058	<.001	<.001	3	9
BRCA	CAVIN2 →	+0.744	+0.034	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080164 vs GPX3 — GBM

Explore this scatter interactively →