Regulation of nitric oxide metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of nitric oxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSTNP1, HSPA4, and CSF3R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric oxide metabolic process activity versus DSTNP1 in GBM (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DSTNP1 →	-0.427	-0.142	.001	<.001	3	5
LSCC	HSPA4 →	-0.309	-0.107	<.001	<.001	3	5
PDAC	CSF3R →	+0.773	+0.130	.002	.001	3	5
COAD	FPR1 →	+0.699	+0.130	.002	.002	3	5
UCEC	RPS3AP13 →	-0.535	-0.139	.003	.001	3	5
COAD	FCGR2C →	+0.759	+0.134	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080164 vs DSTNP1 — GBM

Explore this scatter interactively →