Regulation of nitric oxide metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of nitric oxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSBP4, ZNF491, and NOXA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric oxide metabolic process activity versus SSBP4 in URINARY_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SSBP4 →	+1.076	+0.190	.001	.009	3	5
SOFT_TISSUE	ZNF491 →	+0.952	+0.299	.002	<.001	3	4
PANCREAS	NOXA1 →	-1.262	-0.215	.001	.001	3	4
KIDNEY	SLC39A10 →	+0.927	+0.194	.003	.001	3	4
BLOOD_Leukemia	ZNF836 →	+0.760	+0.108	<.001	.005	3	4
BLOOD_Leukemia	ZNF136 →	+0.588	+0.118	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080164 vs SSBP4 — URINARY_TRACT

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