Intracellular amino acid homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular amino acid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM50, C19orf47, and RPL29P12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular amino acid homeostasis activity versus TIMM50 in OV (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMM50 →	+0.674	+0.108	.007	<.001	3	4
OV	C19orf47 →	+0.555	+0.080	.004	.003	3	4
BRCA	RPL29P12 →	+0.679	+0.091	.002	.001	3	4
CCRCC	MAPK8IP3 →	+0.332	+0.299	.002	.007	2	4
GBM	KIF5A →	+0.672	+0.216	.006	<.001	3	3
CCRCC	EIF5B →	+0.263	+0.346	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080144 vs TIMM50 — OV

Explore this scatter interactively →