Intracellular amino acid homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular amino acid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACD, LMAN2L, and FN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACD grouped by Intracellular amino acid homeostasis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACD →	-1.177	-1.118	<.001	.002	3	6
LUNG_NSCLC_LUAD	LMAN2L →	-0.623	-0.734	<.001	.006	3	5
LUNG_NSCLC_LUAD	FN1 →	-2.734	-0.895	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CCDC80 →	-2.375	-1.083	<.001	<.001	3	5
LUNG_NSCLC_LUSC	TMEM51 →	-1.880	-2.008	.001	<.001	3	5
OVARY	ADPRH →	-0.799	-0.899	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACD by Intracellular amino acid homeostasis activity — BREAST

Explore this box plot interactively →