Intracellular amino acid homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular amino acid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC18B1, PYM1, and APOLD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular amino acid homeostasis activity versus SLC18B1 in LIVER (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC18B1 →	-2.562	-0.209	.002	.004	3	6
BREAST	PYM1 →	-1.086	-0.342	<.001	<.001	3	5
SKIN	APOLD1 →	+2.490	+0.185	.003	.004	3	5
BREAST	ASAP1 →	+1.659	+0.314	.001	<.001	3	5
KIDNEY	SLC2A1 →	+3.159	+0.142	.001	.007	3	5
KIDNEY	TOM1L1 →	-0.910	-0.141	.008	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080144 vs SLC18B1 — LIVER

Explore this scatter interactively →