Viral translational termination-reinitiation

Across TCGA patient cohorts, RNA activity of the Viral translational termination-reinitiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RHBDF2_S387, CA12, and FOXK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral translational termination-reinitiation activity versus RHBDF2_S387 in UCEC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RHBDF2_S387 →	-0.643	-0.073	.001	.008	3	5
LUAD	CA12 →	-0.915	-0.030	.001	<.001	3	5
OV	FOXK1 →	+0.436	+0.042	<.001	<.001	3	5
GBM	ITPRID2 →	-0.342	-0.030	.009	.003	3	5
GBM	SYNPO →	+0.341	+0.034	.003	.001	3	5
LSCC	MAP1B →	+0.654	+0.024	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075525 vs RHBDF2_S387 — UCEC

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