Viral translational termination-reinitiation

Across TCGA patient cohorts, RNA activity of the Viral translational termination-reinitiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB1IP1P1, MIR4282, and CD40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Viral translational termination-reinitiation activity versus CCNB1IP1P1 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCNB1IP1P1 →	-0.312	-0.078	.002	.004	3	4
LUAD	MIR4282 →	-1.086	-0.132	.003	<.001	3	3
LSCC	CD40 →	-0.478	-0.094	.006	.004	3	3
LSCC	AOAH-IT1 →	-0.563	-0.090	.002	<.001	3	3
GBM	MEGF10 →	-1.315	-0.096	.001	.003	3	3
OV	CYSLTR2 →	-0.699	-0.229	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075525 vs CCNB1IP1P1 — HNSC

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