Viral translational termination-reinitiation

Across TCGA cell cohorts, RNA activity of the Viral translational termination-reinitiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP97D1, TNFRSF14, and CYB561A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP97D1 grouped by Viral translational termination-reinitiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CFAP97D1 →	+0.049	+0.128	<.001	<.001	3	4
SOFT_TISSUE	TNFRSF14 →	-1.785	-0.156	.002	.001	3	4
CNS	CYB561A3 →	-0.914	-0.100	.005	.003	3	3
CNS	ADCK5 →	-0.514	-0.100	<.001	<.001	3	3
CNS	EIF1 →	+0.423	+0.084	<.001	.001	3	3
SOFT_TISSUE	GLMP →	-3.953	-0.188	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP97D1 by Viral translational termination-reinitiation activity — OESOPHAGUS

Explore this box plot interactively →