Endocytosis involved in viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Endocytosis involved in viral entry into host cell pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSTC, L3HYPDH, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytosis involved in viral entry into host cell activity versus OSTC in LUAD (Pearson r = -0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OSTC →	-1.111	-0.097	<.001	<.001	3	8
GBM	L3HYPDH →	+0.537	+0.070	<.001	.001	3	8
BRCA	RSU1 →	+0.370	+0.032	<.001	<.001	3	7
BRCA	GSN →	+0.509	+0.026	<.001	<.001	3	7
BRCA	EHD2 →	+0.710	+0.051	<.001	<.001	3	7
GBM	ANXA2 →	+0.465	+0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075509 vs OSTC — LUAD

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