Endocytosis involved in viral entry into host cell

Across TCGA patient cohorts, RNA activity of the Endocytosis involved in viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGDIB, NRARP, and CEP68, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytosis involved in viral entry into host cell activity versus ARHGDIB in LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGDIB →	+0.619	+0.168	<.001	<.001	3	5
LSCC	NRARP →	-1.223	-0.220	<.001	<.001	3	5
HNSC	CEP68 →	-0.459	-0.173	.002	.009	3	5
CCRCC	HNRNPA0 →	-0.319	-0.180	<.001	.002	3	5
HNSC	RMND5A →	-0.451	-0.195	.001	<.001	3	5
UCEC	WNK2 →	-0.839	-0.181	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075509 vs ARHGDIB — LUAD

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