Endocytosis involved in viral entry into host cell

Across TCGA cell cohorts, RNA activity of the Endocytosis involved in viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPCPD1, ODAPH, and TMBIM4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPCPD1 grouped by Endocytosis involved in viral entry into host cell-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GPCPD1 →	+1.292	+1.497	.001	<.001	3	4
KIDNEY	ODAPH →	-0.931	-1.170	.007	<.001	3	4
CNS	TMBIM4 →	-0.653	-1.227	.008	<.001	3	4
LUNG_NSCLC_LUSC	RNF182 →	-1.728	-1.553	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SIX4 →	+0.789	+0.882	.006	.006	3	4
LUNG_NSCLC_LUAD	C1orf54 →	+0.445	+1.031	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPCPD1 by Endocytosis involved in viral entry into host cell activity — KIDNEY

Explore this box plot interactively →