Endocytosis involved in viral entry into host cell

Across TCGA cell cohorts, RNA activity of the Endocytosis involved in viral entry into host cell pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRMT2, SLC30A9, and PRKCA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytosis involved in viral entry into host cell activity versus PRMT2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRMT2 →	+1.120	+0.283	.008	<.001	3	4
CNS	SLC30A9 →	+0.543	+0.270	.008	.003	3	4
LUNG_NSCLC_LUAD	PRKCA →	+0.745	+0.355	.006	.006	3	4
PANCREAS	EXT1 →	+1.186	+0.617	.007	.009	3	4
LUNG_NSCLC_LUAD	KIAA0408 →	+0.971	+0.434	.001	.005	3	4
BLOOD_Myeloma	RAB28 →	+1.119	+1.332	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075509 vs PRMT2 — UPPER_AERODIGESTIVE_TRACT

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