Positive regulation by symbiont of entry into host

Across TCGA cell cohorts, RNA activity of the Positive regulation by symbiont of entry into host pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOLD1, PEX2, and LIPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOLD1 grouped by Positive regulation by symbiont of entry into host-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	APOLD1 →	+1.936	+1.038	.004	.004	3	4
URINARY_TRACT	PEX2 →	-0.589	-1.460	<.001	<.001	3	3
SOFT_TISSUE	LIPA →	+1.440	+1.125	.001	.001	3	3
LARGE_INTESTINE	MRPS30 →	-0.434	-0.784	.004	.007	3	3
SKIN	GPR137B →	+1.946	+1.320	<.001	.001	3	3
OESOPHAGUS	BIRC2 →	+1.468	+0.702	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOLD1 by Positive regulation by symbiont of entry into host activity — SKIN

Explore this box plot interactively →