Positive regulation by symbiont of entry into host

Across TCGA cell cohorts, RNA activity of the Positive regulation by symbiont of entry into host pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B3, LGALS1, and TTC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by symbiont of entry into host activity versus ATP8B3 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP8B3 →	+1.368	+0.190	<.001	<.001	3	7
STOMACH	LGALS1 →	+4.204	+0.227	.002	.004	2	7
BLOOD_Lymphoma	TTC9 →	-1.838	-0.205	<.001	<.001	3	6
OVARY	BSG →	+0.873	+0.209	<.001	.008	3	6
BLOOD_Leukemia	BLNK →	-3.472	-0.221	<.001	<.001	3	5
BREAST	SACS →	+1.519	+0.178	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0075294 vs ATP8B3 — LUNG_NSCLC_LUAD

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