Response to hydroxyurea

Across TCGA patient cohorts, RNA activity of the Response to hydroxyurea pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EDC3, KIF23, and PRC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hydroxyurea activity versus EDC3 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EDC3 →	+0.202	+0.078	<.001	<.001	3	9
LUAD	KIF23 →	+0.827	+0.098	<.001	<.001	3	9
LSCC	PRC1 →	+0.690	+0.083	<.001	<.001	3	9
GBM	ADNP →	+0.329	+0.051	.001	.002	3	9
GBM	CHAF1A →	+0.635	+0.072	<.001	<.001	3	9
GBM	KIFC1 →	+0.722	+0.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072710 vs EDC3 — LSCC

Explore this scatter interactively →