Response to hydroxyurea

Across TCGA cell cohorts, RNA activity of the Response to hydroxyurea pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP8, PCIF1, and RNF20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP8 grouped by Response to hydroxyurea-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GTPBP8 →	+0.607	+0.593	<.001	.005	3	4
SOFT_TISSUE	PCIF1 →	-0.434	-0.273	.001	.004	3	3
SOFT_TISSUE	RNF20 →	-0.871	-0.396	.002	.005	3	3
SOFT_TISSUE	ATF7IP2 →	+3.431	+0.472	<.001	<.001	3	3
SOFT_TISSUE	CCDC189 →	-1.328	-0.398	.005	.001	3	3
SOFT_TISSUE	CBX5 →	-1.270	-0.359	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP8 by Response to hydroxyurea activity — LARGE_INTESTINE

Explore this box plot interactively →