Response to hydroxyurea

Across TCGA cell cohorts, RNA activity of the Response to hydroxyurea pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL34, RAVER1, and MIPEP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to hydroxyurea activity versus MRPL34 in STOMACH (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRPL34 →	+0.857	+0.473	.001	<.001	3	8
BLOOD_Leukemia	RAVER1 →	+0.907	+0.568	<.001	.005	3	7
OVARY	MIPEP →	+0.685	+0.392	.009	<.001	3	6
BLOOD_Lymphoma	TOMM40 →	+1.112	+0.687	.001	.008	3	6
LARGE_INTESTINE	LSM4 →	+0.418	+0.298	.006	.006	2	7
LARGE_INTESTINE	SLC25A33 →	+0.703	+0.319	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072710 vs MRPL34 — STOMACH

Explore this scatter interactively →