T cell extravasation

Across TCGA patient cohorts, RNA activity of the T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM1, IL4I1, and IL27RA, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell extravasation activity versus ICAM1 in ACC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	ICAM1 →	+1.906	+0.057	<.001	<.001	3	30
SCLC	IL4I1 →	+1.921	+0.149	<.001	<.001	3	29
BLCA	IL27RA →	+1.402	+0.064	<.001	<.001	3	29
CHOL	RASAL3 →	+1.555	+0.074	.002	.001	3	29
SARC	GPR84 →	+1.143	+0.064	<.001	<.001	3	29
LAML	LRRC25 →	+2.430	+0.095	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072683 vs ICAM1 — ACC

Explore this scatter interactively →