T cell extravasation

Across TCGA patient cohorts, RNA activity of the T cell extravasation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SASH3, and SEPTIN6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell extravasation activity versus RCSD1 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.430	+0.076	<.001	<.001	3	9
CCRCC	SASH3 →	+0.507	+0.068	<.001	.002	3	9
LSCC	SEPTIN6 →	+0.368	+0.087	<.001	<.001	3	9
BRCA	WIPF1 →	+0.413	+0.056	<.001	<.001	3	9
BRCA	DOK2 →	+0.587	+0.050	<.001	<.001	3	9
LUAD	FNBP1 →	+0.385	+0.066	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072683 vs RCSD1 — LSCC

Explore this scatter interactively →