T cell extravasation

Across TCGA patient cohorts, RNA activity of the T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3G, NAB2, and KIAA1549, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell extravasation activity versus APOBEC3G in BRCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APOBEC3G →	+0.936	+0.269	<.001	<.001	3	6
OV	NAB2 →	-0.378	-0.170	.007	<.001	3	5
GBM	KIAA1549 →	-0.815	-0.214	.004	.001	3	5
LUAD	SLC39A6 →	-0.398	-0.144	.004	.004	3	5
BRCA	JAML →	+0.770	+0.293	.001	<.001	3	5
GBM	PTCRA →	+0.643	+0.218	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072683 vs APOBEC3G — BRCA

Explore this scatter interactively →