T cell extravasation

Across TCGA cell cohorts, RNA activity of the T cell extravasation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPG, ECH1, and GLB1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell extravasation activity versus MPG in BLOOD_Lymphoma (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MPG →	+1.001	+1.617	<.001	<.001	3	3
BLOOD_Lymphoma	ECH1 →	+1.026	+1.541	.002	.001	3	3
BLOOD_Lymphoma	GLB1 →	+0.912	+1.429	<.001	<.001	3	3
BLOOD_Lymphoma	LIMCH1 →	+0.138	+1.510	.001	.001	3	3
BLOOD_Lymphoma	CTSA →	+0.785	+1.475	.005	.001	3	3
BLOOD_Leukemia	LGMN →	-2.389	-0.250	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072683 vs MPG — BLOOD_Lymphoma

Explore this scatter interactively →