Thymocyte migration

pathway activity — cross-omics
GO:0072679Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Thymocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC34A3, RPL38P5, and SNORD53, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASLC34A3 →-0.889-1.542.001<.00133
BRCARPL38P5 →+1.452+1.640.005.00233
HNSCSNORD53 →-0.668-0.540.003.00833
BRCAKCNN4 →+2.561+1.680.003.00232
BRCADNAJC2 →+1.128+1.773<.001<.00132
BRCABCL2L14 →+2.372+2.078.003<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration