T cell migration

Across TCGA patient cohorts, RNA activity of the T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD86, C1QA, and TMEM97, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell migration activity versus CD86 in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD86 →	+0.552	+0.264	.004	.001	3	7
LSCC	C1QA →	+0.715	+0.247	<.001	<.001	3	7
LSCC	TMEM97 →	-1.080	-0.369	<.001	<.001	3	6
GBM	RRAS →	+0.646	+0.342	<.001	<.001	3	6
GBM	TRIM22 →	+0.774	+0.355	.001	.001	3	6
HNSC	GIMAP4 →	+0.657	+0.222	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072678 vs CD86 — LSCC

Explore this scatter interactively →