T cell migration

Across TCGA cell cohorts, RNA activity of the T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CABYR, HROB, and TTC12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CABYR grouped by T cell migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CABYR →	+0.783	+0.624	.006	.006	3	3
BLOOD_Leukemia	HROB →	+0.434	+0.743	.009	.006	3	3
BLOOD_Leukemia	TTC12 →	-1.541	-1.036	<.001	.003	3	3
BLOOD_Leukemia	PACSIN3 →	+1.725	+0.708	<.001	.008	3	3
BLOOD_Leukemia	CALR →	-0.797	-0.768	.006	<.001	3	3
LUNG_SCLC	CEP76 →	+0.640	+0.244	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CABYR by T cell migration activity — LARGE_INTESTINE

Explore this box plot interactively →