T cell migration

Across TCGA cell cohorts, RNA activity of the T cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6AP2, MCM10, and ACCS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell migration activity versus ATP6AP2 in BLOOD_Lymphoma (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ATP6AP2 →	+0.983	+0.353	<.001	.001	3	6
BLOOD_Leukemia	MCM10 →	-1.038	-0.367	<.001	<.001	3	5
KIDNEY	ACCS →	+1.387	+0.299	<.001	<.001	3	5
KIDNEY	DNMT1 →	-0.915	-0.257	<.001	.003	3	5
BLOOD_Leukemia	QSOX1 →	+1.612	+0.326	.001	<.001	3	5
BLOOD_Lymphoma	PPCS →	+0.942	+0.390	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072678 vs ATP6AP2 — BLOOD_Lymphoma

Explore this scatter interactively →