Eosinophil migration

Across TCGA cell cohorts, RNA activity of the Eosinophil migration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACTIN, IMPDH2, and CYP4X1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACTIN grouped by Eosinophil migration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CACTIN →	+0.835	+0.797	.008	.009	3	3
OVARY	IMPDH2 →	+0.582	+0.747	.007	.008	3	3
OVARY	CYP4X1 →	-0.773	-1.286	.004	.003	3	3
BLOOD_Lymphoma	TMEM240 →	+0.492	+1.608	<.001	.009	3	3
BONE	NFATC2 →	+1.576	+1.287	.008	.008	3	3
BONE	ATP9A →	+2.240	+0.995	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACTIN by Eosinophil migration activity — LIVER

Explore this box plot interactively →