Lymphocyte migration

Across TCGA patient cohorts, RNA activity of the Lymphocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPI1, FCGR2A, and APOL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte migration activity versus SPI1 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPI1 →	+0.517	+0.220	.002	<.001	3	6
HNSC	FCGR2A →	+1.001	+0.322	<.001	<.001	2	6
BRCA	APOL1 →	+0.793	+0.195	<.001	.003	3	5
LUAD	NCF4 →	+0.575	+0.166	.005	.007	3	5
OV	TYROBP →	+0.642	+0.160	.002	.003	3	5
PDAC	GPR68 →	+0.774	+0.299	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072676 vs SPI1 — BRCA

Explore this scatter interactively →