Lymphocyte migration

Across TCGA cell cohorts, RNA activity of the Lymphocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF48, DHRS4, and MTA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF48 grouped by Lymphocyte migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF48 →	+0.864	+1.094	.003	.001	3	4
SKIN	DHRS4 →	+0.612	+0.826	<.001	.002	3	4
BLOOD_Myeloma	MTA1 →	+1.902	+1.606	.007	.007	3	4
KIDNEY	NME6 →	-0.589	-1.074	.002	.006	3	4
OVARY	RHOU →	+1.366	+0.756	.002	.004	3	3
BLOOD_Leukemia	PATZ1 →	+0.770	+0.923	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF48 by Lymphocyte migration activity — BLOOD_Leukemia

Explore this box plot interactively →