Lamellipodium morphogenesis

Across TCGA patient cohorts, RNA activity of the Lamellipodium morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNB4, PLXDC2, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lamellipodium morphogenesis activity versus GNB4 in OV (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GNB4 →	+0.452	+0.074	.001	.001	3	9
BRCA	PLXDC2 →	+0.481	+0.040	<.001	<.001	3	9
OV	PRKG1 →	+0.618	+0.079	<.001	<.001	3	9
OV	DOCK11 →	+0.413	+0.062	<.001	<.001	3	9
OV	SGCD →	+0.574	+0.069	.004	.001	3	8
UCEC	STAB1 →	+0.439	+0.117	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072673 vs GNB4 — OV

Explore this scatter interactively →