Neutrophil extravasation

Across TCGA patient cohorts, RNA activity of the Neutrophil extravasation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, MYO1F, and WAS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil extravasation activity versus BIN2 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BIN2 →	+0.827	+0.212	<.001	<.001	3	8
BRCA	MYO1F →	+0.891	+0.208	<.001	<.001	3	8
BRCA	WAS →	+0.885	+0.225	<.001	<.001	3	8
HNSC	SCIMP →	+0.578	+0.303	.001	.003	3	8
GBM	SIRPB2 →	+0.706	+0.258	.002	.001	3	8
BRCA	TNFRSF1B →	+0.944	+0.197	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072672 vs BIN2 — BRCA

Explore this scatter interactively →