Protein localization to vacuole

Across TCGA patient cohorts, RNA activity of the Protein localization to vacuole pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL11, RPS2, and MRPL10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to vacuole activity versus RPL11 in COAD (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL11 →	-0.238	-0.019	<.001	.003	3	7
COAD	RPS2 →	-0.254	-0.022	<.001	.002	3	6
OV	MRPL10 →	-0.442	-0.032	<.001	<.001	3	6
COAD	RPL10A →	-0.194	-0.020	.002	<.001	2	7
BRCA	RPL5 →	-0.174	-0.027	<.001	<.001	3	6
LSCC	MRPL51 →	-0.353	-0.032	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072665 vs RPL11 — COAD

Explore this scatter interactively →