Protein localization to vacuole

Across TCGA cell cohorts, RNA activity of the Protein localization to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBPL3, SH3TC2, and TRAM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSBPL3 grouped by Protein localization to vacuole-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OSBPL3 →	+1.333	+0.208	<.001	<.001	3	5
LARGE_INTESTINE	SH3TC2 →	+1.559	+0.398	.001	<.001	3	4
BONE	TRAM1 →	+1.111	+0.228	.003	.006	3	4
LARGE_INTESTINE	CCDC138 →	-0.682	-0.287	.004	.003	3	4
LARGE_INTESTINE	TMEM265 →	+1.587	+0.253	.002	.009	3	4
SKIN	MAPK1 →	+0.975	+0.272	.004	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSBPL3 by Protein localization to vacuole activity — PANCREAS

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