Protein localization to vacuole

Across TCGA cell cohorts, RNA activity of the Protein localization to vacuole pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL10A, HEXA, and APEX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to vacuole activity versus RPL10A in PANCREAS (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPL10A →	-0.760	-0.290	.003	<.001	3	6
BONE	HEXA →	+1.054	+0.232	.001	.006	3	6
STOMACH	APEX1 →	-0.969	-0.264	.003	.006	3	6
BONE	CCDC88C →	-2.804	-0.289	<.001	<.001	3	6
BONE	SAFB2 →	-0.859	-0.266	<.001	<.001	3	6
PANCREAS	UBTF →	-0.872	-0.204	.008	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072665 vs RPL10A — PANCREAS

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