Protein localization to plasma membrane

Across TCGA patient cohorts, RNA activity of the Protein localization to plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, SEPTIN4, and RPL10A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane activity versus PRKG1 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKG1 →	+0.553	+0.024	<.001	<.001	3	10
GBM	SEPTIN4 →	+0.869	+0.046	<.001	<.001	3	8
OV	RPL10A →	-0.298	-0.030	.001	.004	3	8
GBM	STAB1 →	+0.416	+0.033	<.001	<.001	3	8
LSCC	CLPX →	-0.259	-0.024	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.638	+0.026	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072659 vs PRKG1 — BRCA

Explore this scatter interactively →