Protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO2, CISD3, and TIMP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO2 grouped by Protein localization to plasma membrane-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGO2 →	+0.488	+0.773	.002	<.001	3	3
LUNG_NSCLC_LUAD	CISD3 →	-0.506	-0.701	.004	.002	3	3
BLOOD_Leukemia	TIMP1 →	-1.785	-0.717	.004	.001	3	3
BLOOD_Leukemia	ARL4A →	-1.883	-0.719	.003	.001	3	3
BONE	ZNF485 →	-0.827	-1.533	.002	<.001	3	3
URINARY_TRACT	YJEFN3 →	-2.070	-0.291	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO2 by Protein localization to plasma membrane activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →