Protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC8B1, SLIRP, and EPS8L2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane activity versus SLC8B1 in OESOPHAGUS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC8B1 →	+1.193	+0.063	<.001	.002	3	15
SOFT_TISSUE	SLIRP →	-0.755	-0.045	<.001	.001	3	15
URINARY_TRACT	EPS8L2 →	+3.004	+0.081	<.001	<.001	3	15
OESOPHAGUS	PNPLA2 →	+1.781	+0.095	<.001	<.001	3	15
BONE	RHBDF1 →	+2.259	+0.094	<.001	<.001	3	15
BLOOD_Lymphoma	AHNAK →	+2.903	+0.049	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072659 vs SLC8B1 — OESOPHAGUS

Explore this scatter interactively →