Protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TINAGL1, F3, and ANXA3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane activity versus TINAGL1 in SOFT_TISSUE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TINAGL1 →	+3.096	+0.267	.007	.006	2	11
PANCREAS	F3 →	+4.470	+0.405	.002	.002	3	9
PANCREAS	ANXA3 →	+3.334	+0.353	.004	.004	3	8
PANCREAS	LAMA3 →	+3.596	+0.396	.003	<.001	3	8
PANCREAS	CRYBG2 →	+2.907	+0.605	<.001	<.001	3	8
LUNG_NSCLC_LUAD	ITGB6 →	+2.168	+0.188	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072659 vs TINAGL1 — SOFT_TISSUE

Explore this scatter interactively →