Maintenance of protein location in mitochondrion

Across TCGA patient cohorts, RNA activity of the Maintenance of protein location in mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170B, SETD3, and BAG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in mitochondrion activity versus CEP170B in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEP170B →	+0.490	+0.056	<.001	.008	3	6
CCRCC	SETD3 →	+0.276	+0.074	<.001	<.001	3	5
LSCC	BAG5 →	+0.332	+0.053	<.001	<.001	3	5
LSCC	MTHFD1 →	+0.244	+0.041	<.001	.003	3	5
GBM	NUP88 →	-0.180	-0.063	<.001	<.001	3	5
GBM	ZFYVE21 →	+0.271	+0.068	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072656 vs CEP170B — GBM

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