Maintenance of protein location in mitochondrion

Across TCGA patient cohorts, RNA activity of the Maintenance of protein location in mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WWC2-AS1, PDGFRA, and CLIC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of protein location in mitochondrion activity versus WWC2-AS1 in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	WWC2-AS1 →	+0.076	+0.116	<.001	.005	3	4
LSCC	PDGFRA →	+0.438	+0.107	.002	.002	3	4
LUAD	CLIC4 →	+0.343	+0.117	.003	.001	3	3
GBM	BEX4 →	+0.484	+0.410	.002	.005	3	3
GBM	KIAA1109 →	+0.313	+0.545	<.001	.002	3	3
GBM	CCNG2 →	+0.417	+0.296	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072656 vs WWC2-AS1 — COAD

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