Maintenance of protein location in mitochondrion

Across TCGA cell cohorts, RNA activity of the Maintenance of protein location in mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYL1, UBE2L6, and SPR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LYL1 grouped by Maintenance of protein location in mitochondrion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LYL1 →	-0.600	-0.955	.002	<.001	3	5
LUNG_NSCLC_LUAD	UBE2L6 →	-1.254	-0.718	.005	.005	3	5
OVARY	SPR →	+0.902	+1.109	.004	.003	3	5
LUNG_NSCLC_LUAD	THEMIS2 →	-1.011	-0.733	.002	.005	3	4
LUNG_NSCLC_LUAD	UBA7 →	-1.219	-0.610	.001	.002	3	4
BONE	TMEM214 →	+0.974	+1.588	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LYL1 by Maintenance of protein location in mitochondrion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →