Establishment of protein localization to endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCTN1, KIDINS220, and SEPTIN10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to endoplasmic reticulum activity versus DCTN1 in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCTN1 →	-0.341	-0.123	.007	.007	3	8
LSCC	KIDINS220 →	-0.258	-0.082	.003	<.001	3	6
LSCC	SEPTIN10 →	-0.586	-0.122	.005	.001	3	6
OV	TTC31 →	-0.515	-0.144	.006	.005	3	5
OV	MED12 →	-1.020	-0.163	.004	.002	3	5
CCRCC	ZFYVE9 →	-0.491	-0.201	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072599 vs DCTN1 — BRCA

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