Establishment of protein localization to endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFAND2A, SLC33A1, and SEC61A1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to endoplasmic reticulum activity versus ZFAND2A in CNS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZFAND2A →	+1.010	+0.072	<.001	<.001	3	16
PANCREAS	SLC33A1 →	+1.093	+0.113	<.001	<.001	3	14
BONE	SEC61A1 →	+1.053	+0.090	<.001	.002	3	14
BLOOD_Lymphoma	ALG2 →	+0.735	+0.074	<.001	<.001	3	14
BONE	CCPG1 →	+1.810	+0.092	<.001	<.001	3	13
OVARY	STX5 →	+0.883	+0.089	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072599 vs ZFAND2A — CNS

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