Reactive oxygen species metabolic process

Across TCGA patient cohorts, RNA activity of the Reactive oxygen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CR1, LILRB3, and NLRC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive oxygen species metabolic process activity versus CR1 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CR1 →	+0.889	+0.196	.003	.007	3	5
HNSC	LILRB3 →	+0.901	+0.198	.001	.002	3	5
BRCA	NLRC4 →	+0.321	+0.126	.005	.005	3	5
COAD	ITGAX →	+1.016	+0.136	<.001	<.001	3	5
HNSC	FPR2 →	+1.450	+0.194	.002	<.001	3	5
COAD	NFAM1 →	+0.559	+0.157	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072593 vs CR1 — UCEC

Explore this scatter interactively →