Reactive oxygen species metabolic process

Across TCGA cell cohorts, RNA activity of the Reactive oxygen species metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC75A, SLC7A11, and KDM1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Reactive oxygen species metabolic process activity versus LRRC75A in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRRC75A →	+0.525	+0.190	.007	.001	2	6
LUNG_SCLC	SLC7A11 →	+1.197	+0.208	.007	.001	3	5
OESOPHAGUS	KDM1B →	+1.255	+0.285	<.001	.001	3	5
PANCREAS	ALG5 →	+0.747	+0.215	.005	.005	3	4
BLOOD_Lymphoma	SLC48A1 →	+0.853	+0.125	.009	.008	3	4
URINARY_TRACT	FOXRED2 →	+1.191	+0.335	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072593 vs LRRC75A — BLOOD_Lymphoma

Explore this scatter interactively →