Caveolin-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Caveolin-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH14, MAP1B_S995, and WNK2_S1862, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Caveolin-mediated endocytosis activity versus MYH14 in LSCC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYH14 →	+0.732	+0.082	<.001	<.001	3	5
GBM	MAP1B_S995 →	+0.583	+0.075	<.001	<.001	3	5
LUAD	WNK2_S1862 →	+1.040	+0.073	<.001	<.001	3	4
HNSC	STK26 →	+0.365	+0.075	.002	<.001	3	4
HNSC	THSD1_S655 →	-0.563	-0.081	<.001	.001	3	4
GBM	MAP1B_S541 →	+0.626	+0.064	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072584 vs MYH14 — LSCC

Explore this scatter interactively →