Caveolin-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Caveolin-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACC1, SMAD9, and FEZ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Caveolin-mediated endocytosis activity versus TACC1 in LUAD (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TACC1 →	+0.505	+0.151	<.001	<.001	3	4
PDAC	SMAD9 →	+0.491	+0.139	<.001	.005	3	4
PDAC	FEZ1 →	+0.394	+0.209	<.001	<.001	3	4
PDAC	CA5B →	+0.220	+0.135	<.001	.001	3	4
LUAD	ADAMTS8 →	+0.874	+0.149	<.001	.002	3	3
BRCA	RPL9P16 →	+0.135	+0.155	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072584 vs TACC1 — LUAD

Explore this scatter interactively →