Clathrin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Clathrin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBL2, HERC1, and ZBTB24, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-dependent endocytosis activity versus RBL2 in DLBC (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	RBL2 →	+1.381	+0.056	<.001	<.001	3	34
SCLC	HERC1 →	+1.277	+0.093	<.001	<.001	3	34
CHOL	ZBTB24 →	+1.003	+0.043	.003	<.001	3	34
UVM	NKTR →	+1.367	+0.028	<.001	<.001	3	34
UVM	PIKFYVE →	+1.351	+0.032	<.001	<.001	3	34
DLBC	BIRC6 →	+1.255	+0.055	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072583 vs RBL2 — DLBC

Explore this scatter interactively →