Clathrin-dependent endocytosis

Across TCGA patient cohorts, RNA activity of the Clathrin-dependent endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP2A1, RPL5, and SEPTIN4_S325, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin-dependent endocytosis activity versus AP2A1 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AP2A1 →	+0.225	+0.041	<.001	<.001	3	9
GBM	RPL5 →	-0.257	-0.074	<.001	<.001	3	7
CCRCC	SEPTIN4_S325 →	+0.494	+0.034	.001	.007	3	7
OV	VIM_S22 →	+1.100	+0.052	<.001	.002	3	7
HNSC	CACNA2D1 →	+0.555	+0.046	.003	.004	3	7
BRCA	RSU1 →	+0.347	+0.035	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072583 vs AP2A1 — GBM

Explore this scatter interactively →