Clathrin-dependent endocytosis

Across TCGA cell cohorts, RNA activity of the Clathrin-dependent endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51, NBEAL2, and SCEL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAD51 grouped by Clathrin-dependent endocytosis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RAD51 →	+0.799	+0.296	.005	.005	3	5
STOMACH	NBEAL2 →	+1.545	+0.284	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SCEL →	+2.460	+0.269	.001	<.001	3	4
LUNG_NSCLC_LUAD	ARHGAP22 →	-1.037	-0.174	.004	.005	3	4
LUNG_NSCLC_LUAD	SLC35B4 →	-0.648	-0.281	.004	<.001	3	4
STOMACH	CHMP4B →	+0.802	+0.353	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAD51 by Clathrin-dependent endocytosis activity — STOMACH

Explore this box plot interactively →